Dr. Annette Stange-Marten

Contact

Dr. Annette Stange-Marten

Institute for Zoology and Evolutionary Research
Erbertstrasse 1 (room 008)
07743 Jena
Germany

Tel.: +49 3641/ 949 118
Email: annette.stange-marten@uni-jena.de

Research Interest

Auditory processing describes mechanisms by which animals process sensory auditory input to produce behavioural relevant output. On a neuronal level, input and output are linked by specific neuronal processing circuits. I am interested how these neuronal circuits are adapted to the specific needs of the system.

I studied this in vivo in the most precise auditory system of mammals, the brainstem of Mongolian gerbils. There, I determined the timing of inputs of action potentials in the medial nucleus of the trapezoid body (MNTB) by measuring conduction velocity in globular bushy cell (GBC) fibers and synaptic delays at the Calyx of Held synapse. To this end, I performed in vivo extracellular recordings of MNTB neurons in combination with electrical stimulation of GBC fibers. Furthermore, I investigated the role of precisely timed inhibition for ITD detection in the medial superior olive (MSO) by recording extracellular responses of MSO neurons to auditory stimulation while pharmacologically manipulating the inputs to the MSO.

I recently started to work on neuronal processing circuits in bushcrickets. In this rather simple prothoracic network, neuronal integration of auditory information from the ears in the legs is processed.

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Publications

Five most important Publications

Stange-Marten A, Nabel AL, Sinclair JL, Fischl M, Alexandrova O, Wohlfrom H, Kopp-Scheinpflug C, Pecka M, Grothe B. Input timing for spatial processing is precisely tuned via constant synaptic delays and myelination patterns in the auditory brainstem. PNAS 114:E4851-E4858 (2017)
doi: 10.1073/pnas.1702290114External link

Ford MC, Alexandrova O, Cossell L, Stange-Marten A, Sinclair J, Kopp-Scheinpflug C, Pecka M, Attwell D, Grothe B. Tuning of Ranvier node and internode properties in myelinated axons to adjust action potential timing. Nat Commun 6:8073-8087 (2015)
doi: 10.1038/ncomms9073External link

Dietz M, Marquardt T, Stange A, Pecka M, Grothe B, McAlpine D. 2014 Emphasis of spatial cues in the temporal fine structure during the rising segments of amplitude-modulated sounds II: single-neuron recordings. J Neurophysiol 111(10):1973-1985 (2014)
doi: 10.1152/jn.00681.2013External link

Stange A, Myoga MH, Lingner A, Ford MC, Alexandrova O, Felmy F, Pecka M, Siveke I, Grothe B. Adaptation in sound localization: from GABA(B) receptor-mediated synaptic modulation to perception. Nat Neurosci 16(12):1840-1847 (2013)
doi: 10.1038/nn.3548External link

Escalante-Pérez M, Krol E, Stange A, Geiger D, Al-Rasheid KA, Hause B, Neher E, Hedrich R. A special pair of phytohormones controls excitability, slow closure, and external stomach formation in the Venus flytrap. PNAS 108(37):15492-15497 (2011)
doi: 10.1073/pnas.1112535108External link

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